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目的研究医院肺炎克雷伯菌感染临床特点及其耐药情况,为临床科学选用抗菌药物提供参考。方法通过回顾性分析方法,对某医院住院患者送检病原学标本检测结果进行研究与分析。结果该医院连续2年从住院患者送检的病原学标本中共分离出肺炎克雷伯菌1 127株,肺炎克雷伯菌感染患者主要分布于神经外科,重症监护病房(ICU)和呼吸内科。检出肺炎克雷伯菌的标本以痰液居首位,构成比占68.50%,其次是尿液,占11.18%。临床分离的肺炎克雷伯菌对哌拉西林和氨苄西林耐药率分别为97.34%和94.23%,对碳青霉烯类抗菌药物比较敏感。结论该医院肺炎克雷伯菌感染病例相对集中在神经外科和重症监护病房,该菌对头孢类抗菌药物普遍耐药,应加强耐药菌株监测并参照药敏试验结果合理选用抗菌药物。
Objective To study the clinical characteristics and drug resistance of Klebsiella pneumoniae in hospital and provide a reference for the selection of antibacterials in clinical science. Methods The retrospective analysis method was used to study and analyze the detection results of etiological specimens from inpatients in a hospital. Results A total of 1 127 strains of Klebsiella pneumoniae were isolated from the etiological specimens collected from hospitalized patients for two consecutive years. The patients with Klebsiella pneumoniae infection mainly distributed in neurosurgery, intensive care unit (ICU) and respiratory medicine. Klebsiella pneumoniae samples detected sputum in the first place, accounting for 68.50%, followed by urine, accounting for 11.18%. Klebsiella pneumoniae clinical isolates of piperacillin and ampicillin resistance rates were 97.34% and 94.23%, respectively, for carbapenem antibiotics more sensitive. Conclusion The cases of Klebsiella pneumoniae infection in this hospital are relatively concentrated in the neurosurgery and intensive care unit. The bacteria are generally resistant to cephalosporin antibiotics. The monitoring of drug-resistant strains should be strengthened and the antibacterial drugs should be selected reasonably according to the drug susceptibility test results.