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目的分析探讨高血压合并2型糖尿病患者蛋白尿行依那普利联合氯沙坦治疗的临床疗效。方法选取80例高血压合并2型糖尿病伴有微量蛋白尿患者作为研究对象,按照数字抽签法将其随机分为研究组与对照组,每组40例,研究组行依那普利联合氯沙坦治疗,对照组仅行依那普利治疗,比较两组治疗效果。结果两组患者治疗前SBP、DBP指标比较差异无统计学意义(P>0.05);治疗后,两组患者血压指标均有明显下降(P<0.05),但是两组患者血压指标改善效果比较差异无统计学意义(P>0.05)。治疗前两组患者UAER指标比较差异无统计学意义(P>0.05);治疗后,两组患者UAER指标均有一定程度的下降(P<0.05),其中研究组患者UAER指标改善效果明显优于对照组(P<0.05)。结论氯沙坦联合依那普利治疗高血压合并2型糖尿病微量蛋白尿具有更为显著的临床效果,有助于进一步改善患者早期肾脏损伤,临床疗效显著,可以推广应用。
Objective To investigate the clinical efficacy of enalapril plus losartan in patients with hypertension and type 2 diabetes. Methods Eighty hypertensive patients with type 2 diabetes mellitus and microalbuminuria were enrolled in this study. According to the digital lottery method, they were randomly divided into study group and control group, with 40 cases in each group. The study group was enalapril combined with chlorine Tan treatment, the control group only enalapril treatment, the two groups were compared. Results There was no significant difference in SBP and DBP before treatment between the two groups (P> 0.05). After treatment, the blood pressure indexes of both groups were significantly decreased (P <0.05), but the improvement of blood pressure was significantly different between the two groups No statistical significance (P> 0.05). There was no significant difference in UAER index between the two groups before treatment (P> 0.05). After treatment, the UAER index of both groups decreased to a certain extent (P <0.05), and the improvement effect of UAER in study group was better than that of UAER Control group (P <0.05). Conclusion Losartan combined with enalapril treatment of hypertension with type 2 diabetes microalbuminuria has more significant clinical effects, help to further improve the early renal injury in patients with significant clinical efficacy, and can be extended.