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口腔粘膜溃疡坏死性病变,其蛋白水解酶活性过高,对粘膜的蛋白结构有损害作用,为使组织蛋白水解过多正常,利用蛋白水解酶抑制剂。作者用生物化学的方法,研究患者的混合唾液和溃疡灶渗出液,探讨用蛋白酶抑制剂Contrycal治疗口腔粘膜坏死性病变的理论根据。检查30例病人和20名健康人作对照,测定混合唾液的蛋白水解酶活性、溶菌酶活性和蛋白含量,研究不同浓度的Contrycal对混合唾液或溃疡渗出液蛋白水解酶活性的影响。研究结果:口腔粘膜溃疡坏死性病变患者的混合唾液中蛋白水解系统活性增高,蛋
Oral mucosal ulcer necrosis, the proteolytic enzyme activity is too high, the mucosal protein structure has a detrimental effect, in order to make excessive normal tissue proteolysis, the use of protease inhibitors. The authors used biochemical methods to study patients with mixed saliva and ulceration exudate, to explore the protease inhibitor Contrycal theoretical basis for the treatment of oral mucosal necrosis. 30 patients and 20 healthy volunteers were examined as control. The proteolytic enzyme activity, lysozyme activity and protein content of mixed saliva were measured to study the effects of different concentrations of Contrycal on proteolytic activity of mixed saliva or ulcer exudate. Results: Oral ulcer necrosis in patients with mixed saliva proteolytic activity, egg