论文部分内容阅读
目的探讨ｒａｓＰ２１和Ｐ５３表达与膀胱移行细胞癌病理分级、临床分期、复发、肿瘤大小及患者年龄的关系。方法采用免疫流式细胞光度术与病理学相结合的方法对４７例膀胱移行细胞癌细胞ｒａｓＰ２１和Ｐ５３蛋白表达进行检测分析。结果ｒａｓＰ２１和Ｐ５３阳性表达率随病理分级升高而渐升高（Ｐ＜０．０５）。Ｔ２～Ｔ４期ｒａｓＰ２１、Ｐ５３的阳性表达率高于Ｔ１期（Ｐ＜０．０５）。ｒａｓＰ２１阳性者复发率为５１．６％（１６／３１），阴性者１２．５％（２／１６），Ｐ５３阳性者复发率为４５．７％（１６／３５），阴性者１６．６％（２／１２）。ｒａｓＰ２１、Ｐ５３的阳性表达率与肿瘤大小及患者的年龄无统计学差异。结论ｒａｓＰ２１和Ｐ５３的表达可反映膀胱移行细胞癌的恶性程度和预后，可作为临床上有价值的指标
Objective To investigate the relationship between the expression of rasP21 and P53 and the pathological grade, clinical stage, recurrence, tumor size and patient’s age in bladder transitional cell carcinoma. Methods The expression of rasP21 and P53 protein in 47 cases of bladder transitional cell carcinoma was detected by immunofluorescence cytometry combined with pathology. Results The positive rates of rasP21 and P53 were gradually increased with the pathological grading (P <0.05). The positive rates of rasP21 and P53 from T2 to T4 were higher than those from T1 (P <0.05). The recurrence rate was 51.6% (16/31) in rasP21 positive group, 12.5% (2/16) in negative group, 45.7% (16/35) in negative group and 16.6% in negative group (2/12). The positive rates of rasP21 and P53 were not significantly different from the tumor size and the patient’s age. Conclusion The expression of rasP21 and P53 may reflect the malignant degree and prognosis of bladder transitional cell carcinoma and may be used as a clinically valuable indicator