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目的研究螺内酯联合地尔硫?治疗舒张性心力衰竭的疗效。方法将2015年1月~2016年3月舒张性心力衰竭患者116例随机分为两组。常规治疗组用常规治疗,联合治疗组于常规治疗组基础上用螺内酯联合地尔硫?治疗。比较两组患者舒张性心力衰竭治疗总有效率,药物不良反应发生情况,治疗前后患者6 min步行距离、脑钠肽、E/A比值的差异。结果治疗后,联合治疗组患者舒张性心力衰竭治疗总有效率高于常规治疗组,联合治疗组6 min步行距离、脑钠肽、E/A比值比常规治疗组改善幅度更大,差异均有统计学意义(P<0.05);两组药物不良反应发生情况无显著差异(P>0.05)。结论螺内酯联合地尔硫?治疗舒张性心力衰竭的疗效确切,可促进临床症状消退,改善患者心功能和耐力情况,降低脑钠肽水平,无严重不良反应,安全可靠。
Objective To study the efficacy of spironolactone combined with diltiazem in the treatment of diastolic heart failure. Methods From January 2015 to March 2016, 116 patients with diastolic heart failure were randomly divided into two groups. The conventional treatment group with conventional treatment, the combined treatment group in the conventional treatment group based on spironolactone combined diltiazem? Treatment. The total effective rate of treatment of diastolic heart failure, incidence of adverse drug reactions, the walking distance of 6 min and the ratio of brain natriuretic peptide and E / A in patients before and after treatment were compared between the two groups. Results After treatment, the total effective rate of treatment of diastolic heart failure in the combination therapy group was higher than that of the conventional therapy group. The distance of 6 min in the combination therapy group was higher than that in the conventional therapy group, and the difference was statistically significant Statistical significance (P <0.05); There was no significant difference in adverse drug reaction between the two groups (P> 0.05). Conclusion Spironolactone combined with diltiazem treatment of diastolic heart failure, the exact effect can promote the regression of clinical symptoms, improve patient cardiac function and endurance, reduce the level of brain natriuretic peptide, no serious adverse reactions, safe and reliable.