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目的观察慢性阻塞性肺病(COPD)患者急性加重期外周血白细胞介素-6(IL-6)和白细胞介素-8(IL-8)指标变化。方法连续选择COPD急性加重期患者33例,开始治疗前进行血清IL-6和IL-8浓度检测,并与同期住院27例COPD缓解期患者和31例健康体检者相同检测结果比较。结果 COPD急性加重期患者血清IL-8和IL-6浓度明显高于COPD缓解期组和对照组,同时COPD缓解期患者血清IL-8和IL-6浓度也明显高于对照组(P<0.01～0.05)。结论 COPD患者急性加重期存在明确的外周血IL-8和IL-6水平高强度表达。
Objective To observe the changes of peripheral blood interleukin-6 (IL-6) and interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD) at acute exacerbation. Methods Thirty-three consecutive patients with acute exacerbation of COPD were enrolled in this study. Serum levels of IL-6 and IL-8 were measured before treatment. The results were compared with those of 27 patients with COPD during the same period and 31 healthy controls. Results Serum levels of IL-8 and IL-6 in patients with acute exacerbation of COPD were significantly higher than those in COPD-remission and control groups, and serum concentrations of IL-8 and IL-6 in patients with COPD were significantly higher than those in controls (P <0.01) ~ 0.05). Conclusion There is a clear expression of IL-8 and IL-6 in peripheral blood in patients with acute exacerbation of COPD.