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目的:探讨吸入一氧化氮(i NO)治疗新生儿HRF的疗效及安全性。方法:将96例HRF患儿分为实验组56例和对照组40例,实验组患儿给予常频机械通气+i NO治疗,对照组患儿给予常频机械通气+静滴扩血管药物硫酸镁治疗,比较两组患儿机械通气时间、总氧疗时间、治疗24 h后血气分析指标水平以及并发症发生情况。结果:实验组患儿机械通气时间及总氧疗时间均显著低于对照组(P<0.05);实验组患儿24 h p H值、Pa O2、Pa O2/Fi O2及Sa O2水平均显著高于对照组(P<0.05),Pa CO2和OI均显著低于对照组(P<0.05);两组患儿并发症发生率比较,差异无统计学意义(P>0.05)。结论:i NO能够有效改善HRF患儿氧合功能,纠正高碳酸血症和酸中毒,缩短治疗时间,且不增加不良反应,安全性较高。
Objective: To investigate the efficacy and safety of inhaled nitric oxide (NO) in neonatal HRF. Methods: Ninety-six children with HRF were divided into experimental group (56 cases) and control group (40 cases). The experimental group was given normal-frequency mechanical ventilation and i-NO treatment, while the control group was given regular mechanical ventilation and intravenous drip- Magnesium treatment, mechanical ventilation time, total oxygen therapy time, blood gas analysis index level after 24 h treatment and complication occurred in both groups. Results: The duration of mechanical ventilation and the total duration of oxygen therapy in experimental group were significantly lower than those in control group (P <0.05). The values of 24 hp H, Pa O2, Pa O2 / Fi O2 and Sa O2 in experimental group were significantly higher than those in control group PaCO2 and OI in the control group (P <0.05) were significantly lower than those in the control group (P <0.05). There was no significant difference in the complication rates between the two groups (P> 0.05). Conclusion: i NO can effectively improve the oxygenation function in children with HRF, correct hypercapnia and acidosis, shorten the treatment time, and do not increase adverse reactions, safety is higher.