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目的 :为探讨合理的麻醉深度监测指标 ,观察了大剂量芬太尼麻醉对 2 4例家兔脑干听觉诱发电位 (BAEP)及 40Hz听觉稳态电位 ( 4 0Hz ASSR)的影响。方法 :实验组分 3次静注总量 90 μg/kg芬太尼 ,对照组注射等量生理盐水。于首次给药前及给药后 5、2 5、45分钟测定 80、60、50dBnHL下BAEP及 1 2 0、1 1 0、1 0 0dBnHL下 40Hz ASSR波形变化及阈值强度。结果 :随着血浆芬太尼浓度逐渐升高 ,各声强下BAEPⅠ、Ⅱ、Ⅳ波潜伏期 ,振幅 ,Ⅰ Ⅱ、Ⅱ Ⅳ、Ⅰ Ⅳ波间期无明显改变 ,各测定点阈值强度无改变 ;而各声强下 40Hz ASSRPa、Pb波潜伏期逐渐延长 ,振幅下降 ,各测定点阈值强度逐渐增高。结论 :与BAEP相比 ,1 2 0、1 1 0、1 0 0dBnHL声强下 40Hz ASSR是监测大剂量芬太尼麻醉深度的可靠指标
Objective: To explore a reasonable indicator of anesthetic depth and observe the effects of high-dose fentanyl on brainstem auditory evoked potential (BAEP) and 40 Hz auditory steady-state potential (40 Hz ASSR) in 24 rabbits. Methods: The experimental components were intravenously injected three times in a total amount of 90 μg / kg fentanyl, and the control group was injected with the same amount of normal saline. BAEP at 40, 60 and 50 dBnHL and 40 Hz ASSR waveform at 120, 110 and 100 dBnHL were measured before the first administration and at 5, 25, 45 minutes after administration. Results: With the increase of plasma fentanyl concentration, there was no significant change in the latency, amplitude of wave, Ⅰ Ⅱ, Ⅱ Ⅳ, Ⅰ Ⅳ wave duration of BAEP Ⅰ, Ⅱ, Ⅳ at each sound intensity. While the 40Hz ASSRPa and Pb wave amplitudes gradually increased and the amplitudes decreased, the threshold intensity of each measurement point increased gradually. Conclusion: Compared with BAEP, the 40 Hz ASSR at 120, 110 and 100 dBnHL intensity is a reliable indicator of the anesthetic depth of large-dose fentanyl