论文部分内容阅读
用挤出 /滚圆法以茶碱为模型药物研制快速崩解包衣小丸骨架片。以 Eudragit NE30 D或 RL /RS30 D为包衣材料 ,用底喷式流化床包衣 ,再压制成骨架片。对包衣材料的种类、压片辅料的组成和用量、压片力等因素进行了考察优化 ,得到了符合美国药典释放度要求的包衣小丸骨架片。
Using extrusion / spheroidisophylline as model drug to develop rapidly disintegrating coated pellets pellets. Eudragit NE30 D or RL / RS30 D as the coating material, with a bottom spray fluidized bed coating, and then pressed into the matrix pieces. The types of coating materials, the composition and amount of tabletting auxiliary materials, the tabletting force and other factors were investigated and optimized, and the coated pellets with the requirements of the release degree of the United States Pharmacopoeia were obtained.