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检测替硝唑（ｔｉｎｉｄａｚｏｌｅ，ＴＮＺ）对６３ 株口腔常见厌氧病原菌的体外抗菌活性，其ＭＩＣ和ＭＢＣ值范围为≤０．１２５～１６ｍ ｇ／Ｌ，与甲硝唑（ｍ ｅｔｒｏｎｉｄａｚｏｌｅ，ＭＮＺ）比较，结果相近或略低。采用厌氧培养方法，检测４８名牙周炎和冠周炎患者服用ＴＮＺ和ＭＮＺ前后病灶位厌氧菌的检出情况，结果显示ＴＮＺ对卟啉单胞菌、普雷沃氏菌、梭杆菌和消化链球菌有强的抗菌活性，用药后的菌量明显减少，有统计学意义（Ｐ＜ ０．０１），其体内抗菌活性与ＭＮＺ相似或略强。
The antibacterial activity of tinidazole (TNZ) on 63 strains of common oral anaerobic pathogens was tested. The MIC and MBC values ranged from 0.125 to 16 m g / L, compared with that of metronidazole (MNZ) With similar or slightly lower results. The anaerobic culture method was used to detect the anaerobes detected in 48 patients with periodontitis and peri-periitis before and after taking TNZ and MNZ. The results showed that TNZ was effective against Porphyromonas, Prevotella, Fusobacterium And Peptostreptococcus have strong antibacterial activity, the amount of bacteria decreased significantly after treatment, with statistical significance (P <0.01), the antibacterial activity in vivo similar and slightly stronger MNZ.