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采用双盲随机化方式,评价还原酶Fluvastatin单独或与烟酸联合用药治疗饮食控制无效的高胆固醇血症的疗效和安全性。 病例来自1990年10月至1992年7月间两个研究中心的74例高胆固醇血症患者,年龄在21岁至70岁之间,诊断符合:LDL-C≥160mg/dL,甘油三酯≤350mg/dL。随机分为Fluvastatin加烟酸组38例,烟酸加安慰剂组36例。两组分别服用降脂药Fluvasta-
The efficacy and safety of reductase Fluvastatin alone or in combination with nicotinic acid in the treatment of hypercholesterolemia with poor diet control were evaluated by a double-blind randomized trial. The cases were from 74 patients with hypercholesterolemia at two research centers between October 1990 and July 1992, ranging in age from 21 to 70 years. The diagnosis was in accordance with the following criteria: LDL-C≥160mg / dL, triglyceride≤ 350 mg / dL. Randomly divided into Fluvastatin plus niacin 38 cases, niacin plus placebo 36 cases. Two groups were taken lipid-lowering drugs Fluvasta-