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目的 :研究中枢神经细胞瘤 (centralneurocytoma ,CNC)的临床病理特征 ,以提高对此瘤的认识 ,避免误诊。 方法 :对 7例CNC的临床病理特征进行分析 ,并做免疫组化检测以证实其性质。结果 :7例CNC均为年青人 ,肿瘤均位于侧脑室内。组织由密集的小圆形细胞组成 ,胞浆透明 ,有核周晕 ,呈蜂窝状结构 ,并有无细胞性神经原纤维岛特征。免疫组化Syn和NSE阳性 ,GFAP和NF阴性。结论 :CNC是分化好的神经元细胞组成的良性肿瘤 ,好发于年青人脑室内。在光镜下 ,与少突胶质细胞瘤和透明细胞室管膜瘤不易区别 ,无细胞性原纤维岛特征性结构和Syn阳性、GFAP阴性免疫反应有助于鉴别诊断。
Objective: To study the clinicopathological features of central neurocytoma (CNC) to improve the understanding of this tumor and avoid misdiagnosis. Methods: The clinical and pathological features of 7 cases of CNC were analyzed and immunohistochemistry was performed to confirm its nature. Results: 7 cases of CNC are young people, the tumors are located in the lateral ventricle. Tissue composed of dense small round cells, cytoplasm transparent, halo around the nucleus, was honeycomb structure, and cell-free neurofibrillary island features. Immunohistochemical Syn and NSE positive, GFAP and NF negative. Conclusion: CNC is a benign tumor composed of well-differentiated neurons, which occurs in young people’s brain. Under light microscope, with oligodendroglioma and clear cell ependymoma is not easy to distinguish, acellular fibrillar island characteristic structure and Syn positive, GFAP negative immune reaction contribute to the differential diagnosis.