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本文用α—醋酸萘酯酶(ANAE)反应标记淋巴细胞的化学方法,对从平原地区移居到青海玉树地区(海拔3800m),3—8个月内的78例正常青年人(汉族)及世居玉树地区105例正常藏族青年人外周血淋巴细胞阳性率进行了研究。移居组青年人外周血T细胞的总阳性率为61.13±6.44%;世居组青年人外周血T细胞的总阳性率为77.96±6.83%。结果表明,移居组青年人外固血T细胞ANAE总阳性率及“点状颗粒型”显著低于世居组青年人(P<0.01),而移居组“弥散颗粒型”T细胞的百分率高于世居组(P<0.05)。结果还表明世居藏族青年人T细胞的正常值与国内外各民族健康青年人正常值相接近,本实验结果提示两点:①高原缺氧对移居人群的免疫功能有一定影响,可引起T细胞亚群之间的协调关系失去平衡,是高原易罹患感冒病毒等感染性疾病的佐症。②为世居藏族人群对高原适应机制提供了一个有意义的参数。
In this study, 78 normal young people (Han nationality) who migrated from the plains to Yushu in Qinghai Province (3800 m above sea level) within 3-8 months were treated with ANAE reaction labeled with lymphocytes. The positive rates of peripheral blood lymphocytes in 105 normal Tibetan young people in Yushu district were studied. The positive rate of T cells in peripheral blood of migrant young adults was 61.13 ± 6.44%. The total positive rate of T cells in peripheral blood of young adults was 77.96 ± 6.83%. The results showed that the positive rate of ANAE and the “dot-like granular type” of peripheral blood T lymphocyte in migrant group were significantly lower than those in the native group (P <0.01), while those of the migratory group “diffuse granular type” T cell The percentage was higher than that of the native group (P <0.05). The results also show that the normal Tibetan young people living with T lymphocytes normal and healthy ethnic groups at home and abroad close to normal, the experimental results suggest that two points: ① plateau hypoxia on immune function of immigrants have a certain impact, can cause T The coordination relationship between cell subsets loses balance and is an adjunct to infectious diseases such as cold virus susceptible to altitude sickness. ② provides a meaningful parameter for the adaptation mechanism of the Tibetan Plateau to the Tibetan population.