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目的 在早期和晚期动脉粥样硬化模型上研究新化合物哌芳安他抗动脉粥样硬化的机制。方法 大鼠或家兔随机分为正常对照、模型对照和哌芳安他给药组 ,其中模型对照和哌芳安他给药组动物给予高胆固醇饲料 ,检测的指标包括 :兔颈动脉HE染色 ;大鼠或兔血清TC ,LDL CHO ,HDL CHO ,IL 8,ET 1,PGI2 ,TXA2 和NO水平 ;兔颈动脉MCP 1和IL 8mRNA表达量。结果 哌芳安他能明显抑制早期和晚期动脉粥样硬化中TXA2 的过量表达 ,在大鼠早期动脉粥样硬化中可见哌芳安他给药组动物血清NO增加而IL 8含量减少 ;在兔晚期动脉粥样硬化中可见IL 8和MCP 1mRNA表达降低 ;哌芳安他对血脂水平、MDA和SOD无明显影响。结论 哌芳安他抗动脉粥样硬化机制与其升高血清NO水平 ,降低TXA2 含量及抑制IL 8和MCP 1过度表达相关。
OBJECTIVE: To study the mechanism of the new compound, piafopantatol atherosclerosis, in early and late models of atherosclerosis. Methods Rats or rabbits were randomly divided into normal control group, model control group and pefloxacin group. High cholesterol diet was given to the model control and the pirafrenac group, and the indexes of the test included rabbit carotid artery HE staining , The levels of TC, LDL CHO, HDL CHO, IL 8, ET 1, PGI 2, TXA 2 and NO in rat or rabbit serum; Results Piperfantamide significantly inhibited the over-expression of TXA2 in early and advanced atherosclerosis. In the early stage of atherosclerosis in rats, the concentration of NO was increased and the content of IL-8 was decreased in the treated group In atherosclerotic stage, the expression of IL-8 and MCP-1 mRNA was decreased. Piperfamil had no effect on blood lipid level, MDA and SOD. Conclusion Piperine anti-atherosclerotic mechanism is related to increasing serum NO level, decreasing TXA2 content and inhibiting IL 8 and MCP 1 overexpression.