抗原提呈细胞(APC)是影响细胞因子性质的因素之一。本研究采用已建立的T细胞株分析表达不同粘附分子的各种APC对T细胞增殖和细胞因子分泌的影响。对CD_4~+、抗原特异性、同种异体特异性T细胞株进行了分析,各种细胞株在PMA和Ionomycin的刺激下均能产生IL-2、IL-4、γ干扰素和α-肿瘤坏死因子,但IL-4和γ干扰素或α-肿瘤坏死因子之间的比率变化很大。受抗原刺激后所产生的 Antigen-presenting cells (APCs) are one of the factors that influence the nature of cytokines. In this study, the established T cell lines were used to analyze the effects of various APCs expressing different adhesion molecules on T cell proliferation and cytokine secretion. CD_4 ~ +, antigen-specific, allogeneic specific T cell lines were analyzed, all kinds of cell lines can produce IL-2, IL-4, IFNγ and α-tumor under the stimulation of PMA and Ionomycin Necrosis factor, but the ratio between IL-4 and interferon gamma or alpha-tumor necrosis factor varies widely. Produced by antigen stimulation