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血栓性血小板减少性紫癜(TTP)是罕见的暴发性疾患,其特征是:微血管病性溶血性贫血,血小板减少,神经系统和肾脏的异常和发热。抗血小板聚集剂前列环素(前列腺素 I_2;PGI_2)的缺乏,可能解释TTP 中出现的血小板消耗和广泛的弥散性血管内血栓形成。本研究的目的是为查明 PGI_2缺乏是否与TTP 的发病有关。作者叙述了2例 TTP 患者,其中1例曾输注 PGI_2,并报道了这2例患者在治疗前以及对照组中健康志愿者的6-氧-前列腺素 F_(1α)。(6-OXO-PGF_(1α))和血栓素 B_2的浓度。
Thrombotic thrombocytopenic purpura (TTP) is a rare fulminant disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, abnormalities of the nervous system and kidneys, and fever. The lack of prostacyclin (prostaglandin I 2; PGI 2), an antiplatelet aggregator, may account for the platelet depletion and extensive disseminated intravascular thrombosis that occurs in TTP. The purpose of this study was to determine if PGI2 deficiency was associated with the pathogenesis of TTP. The authors described two TTP patients, one of whom had been infused with PGI_2 and the 6-oxo-prostaglandin F_ (1α) of 2 healthy volunteers before and during the treatment period. (6-OXO-PGF_ (1α)) and thromboxane B_2.