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本实验室曾证明,钙拮抗药硝苯吡啶对人和大鼠肝微粒体代谢(-)-和(+)-吡喹酮均有竞争性抑制作用。为进一步探明硝苯吡啶在体内对吡喹酮代谢的影响,本实验以硝苯吡啶40mg/kg,ip单剂给药后,采用反相高效液相色谱法测定消旋吡喹酮(100mg/kg,ig)在大鼠体内的血浆浓度,所得药代动力学参数:AUC、MRT、CL、T_min、C_min,与对照组相比均无显著差异,表明在该剂量下硝苯吡啶ip单剂给药对吡喹酮存大鼠体内的药代动力学无明显影响
Our laboratory has demonstrated that the calcium antagonist nifedipine has a competitive inhibitory effect on the metabolism of (-) - and (+) - praziquantel in human and rat liver microsomes. In order to further explore the effect of nifedipine on the metabolism of praziquantel in vivo, nifedipine 40mg / kg, ip single dose after the experiment, using reversed-phase high performance liquid chromatography determination of racemic praziquantel (100mg / kg, ig) in rats plasma concentration, pharmacokinetic parameters obtained: AUC, MRT, CL, T_min, C_min, compared with the control group were no significant difference, indicating that at this dose of nifedipine ip single Pharmacokinetics of praziquantel in rats has no significant effect on the pharmacokinetics