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维甲酸是一类很有效的药物,但也有很强的致畸作用.本文介绍了13-顺维甲酸和依曲替酯的致畸作用的流行病学情况.在用这两种药物期间怀孕的妇女生产畸胎高达50%,停用维甲酸后相当长时间仍有致畸作用.因此用药前后避孕非常重要.本文同时介绍现代避孕常见的几种方法的作用原理、效果、副作用、使用注意事项及用维甲酸治疗期间的避孕选择和方法.
Retinoic acid is a very effective class of drugs but also has a strong teratogenic effect This article describes the epidemiology of the teratogenic effects of 13-cistrinoic acid and itraquitin. During pregnancy with both drugs Of women produce teratogenic up to 50%, after deactivating retinoic acid for a long time there are still teratogenic effects .Therefore contraception is very important before and after treatment.This article also introduces the principle of several common methods of modern contraception, effects, side effects, precautions And contraceptive options and methods during treatment with tretinoin.