论文部分内容阅读
目的:比较阿奇霉素与红霉素-阿奇霉素序贯治疗儿童支原体肺炎的疗效。方法:选取54例儿童支原体肺炎为研究对象,随机分为观察组和对照组各27例,观察组静脉滴注红霉素5天,体温下降后改为阿奇霉素静脉滴注5天,停药4天后改为口服阿奇霉素;对照组静脉滴注阿奇霉素5天,停药4天后口服阿奇霉素治疗。治疗3周后比较两组患儿的症状、体征消退时间、疾病转归、并发症以及费用。结果:①观察组治愈24例,治愈率为88.9%,住院时间为(9.1±1.5)天,住院费用(1 317.5±326.1)元,对照组治愈23例,治愈率85.2%,住院时间为(13.2±1.9)天,住院费用(2 085.9±635.5)元,两组患儿治愈率无统计学差异,但观察组住院时间及医疗费用显著低于对照组(P<0.05)。②观察组患儿平均退热时间、止咳时间、扁桃体充血消失时间以及啰音消失时间均显著低于对照组患儿(P<0.05)。③对照组注射局部疼痛,ALT增高等并发症显著高于观察组(P<0.05)。结论:红霉素-阿奇霉素序贯与单用阿奇霉素治疗效果相似,但症状、体征消失时间更短,并且可减少治疗相关并发症,节省医疗成本。
Objective: To compare the efficacy of azithromycin and erythromycin - azithromycin sequential therapy in children with mycoplasma pneumonia. Methods: Fifty-four cases of children with mycoplasma pneumonia were selected as study subjects and randomly divided into observation group and control group, with 27 cases in each group. The observation group received erythromycin intravenously for 5 days, the body temperature dropped to 5 days after azithromycin infusion, Days after oral azithromycin; control group intravenous azithromycin 5 days, 4 days after withdrawal oral azithromycin treatment. After 3 weeks of treatment, the symptoms, signs and symptoms, prognosis, complications and costs of the two groups were compared. Results: ① The observation group was cured in 24 cases, the cure rate was 88.9%, the hospitalization time was 9.1 ± 1.5 days, the hospitalization cost was 1 317.5 ± 326.1 yuan, the control group was cured in 23 cases, the cure rate was 85.2% 13.2 ± 1.9) days, and hospitalization expense (2 085.9 ± 635.5) yuan. There was no significant difference in the cure rate between the two groups, but the hospitalization time and medical expenses in the observation group were significantly lower than those in the control group (P <0.05). ② The average antipyretic time, cough time, disappearance of tonsil congestion and disappearance of rales in observation group were significantly lower than those in control group (P <0.05). ③ In the control group, the complications such as local pain and increased ALT were significantly higher than those in the observation group (P <0.05). Conclusion: Erythromycin - azithromycin sequential and azithromycin alone treatment effect is similar, but the symptoms and signs disappear shorter, and can reduce the treatment - related complications and save medical costs.