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目的 :探讨肝癌患者血脂及总胆汁酸水平的变化及其临床意义。方法 :测定 40例肝癌患者总胆固醇 (TC)、甘油三脂(TG)、高密度脂蛋白 (HDL -C)、低密度脂蛋白 (LDL -C)、载脂蛋白A1(APOA1)、载脂蛋白B(APOB)、脂蛋白a[LP(a) ]及总胆汁酸 (TBA)水平 ,并以 90例健康人作为对照。结果 :肝癌患者各项指标水平 ( x±s)分别为TC 3 .85± 1.16,TG 1.0 5± 0 .63 ,HDL -C 0 .91± 0 .5 1,LDL -C 2 .74± 0 .88,APOA10 .73± 0 .3 5 ,APOB 0 .87± 0 .3 4,LP(a) 78.2 6± 5 5 .48,TBA 2 9.3 2± 10 .17,对照组各项指标为TC 4.2 8± 0 .72 ,TG1.98± 1.5 8,HDL -C 1.3 1± 0 .2 8,LDL -C2 .96± 0 .67,APOA11.3 5± 0 .2 0 ,APOB 0 .91±0 .2 9,LP(a) 15 3 .63± 112 .65 ,TBA 8.0 2± 2 .15 ,经统计学处理表明TC、TG、APOA1、HDL -C、LP(a)均低于对照组 ,TBA高于对照组 ,而LDL -C、APOB与对照组比较无显著性差异。结论 :肝癌患者存在血脂水平的代谢紊乱 ;检测肝癌患者的血脂及总胆汁酸水平 ,对于观察病情具有实用的临床意义。
Objective: To investigate the changes of serum lipid and total bile acid levels in patients with hepatocellular carcinoma and their clinical significance. METHODS: Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), apolipoprotein A1 (APOA1), and apolipoprotein were measured in 40 patients with hepatocellular carcinoma. Protein B (APOB), lipoprotein a [LP(a)] and total bile acid (TBA) levels, and 90 healthy subjects served as controls. Results: The level of each indicator (x±s) in patients with hepatocellular carcinoma was TC 3.85± 1.16, TG 1.0 5± 0 .63, HDL-C 0.91±0.51, LDL-C 2.74±0. .88, APOA10.73±0.35, APOB 0.87±0.34, LP(a) 78.2 6±5 5.48, TBA 2 9.3 2±10 .17, each index in the control group was TC 4.2 8 ± 0 .72, TG 1.98± 1.5 8, HDL-C 1.3 1± 0.2, LDL-C 2.96± 0 .67, APOA 11.3 5± 0 .2 0, APOB 0 .91± 0.2 9, LP(a) 15 3 .63± 112 .65, TBA 8.0 2± 2.15, Statistical analysis showed that TC, TG, APOA1, HDL-C and LP(a) were all lower than the control group. TBA was higher than the control group, while there was no significant difference between LDL-C, APOB, and the control group. Conclusion: There is a metabolic disorder of blood lipids in patients with liver cancer. Detection of serum lipids and total bile acid levels in patients with liver cancer has practical clinical significance for the observation of the disease.