肿瘤生物学研究认为 ,肿瘤是 1类细胞增殖周期紊乱性疾病 ,表现为细胞增殖加速和凋亡障碍。细胞增殖周期的异常会导致细胞的分裂、增殖和分化的异常 ,促进肿瘤发生。乳腺癌是女性最常见的恶性肿瘤之一 ,它的发生、发展与细胞周期改变密切相关。正常细胞周期分为Ｇ1、Ｓ、Ｇ2 、 Tumor biology studies suggest that tumors are a type 1 disorder of cell proliferation cycle, manifested as accelerated cell proliferation and apoptosis. Abnormalities in the cell proliferation cycle can lead to abnormal cell division, proliferation and differentiation, and promote tumorigenesis. Breast cancer is one of the most common malignant tumors in women. Its occurrence and development are closely related to changes in the cell cycle. The normal cell cycle is divided into G1, S, G2,