HIF-1是低氧反应中的一种核转录调节因子,它包括两个亚基HIF-1α和HIF-1β,其中HIF-1α表达受细胞氧浓度的调节。低氧预处理可诱导机体内源性调节机制,包括多种基因的表达和不同转录因子的激活等,其中HIF-1与脑缺血耐受的形成关系密切,低氧可能通过上调HIF-1的表达及活性,从而诱导其靶基因的表达,诱导脑缺血耐受的形成来保护脑组织。 HIF-1, a nuclear transcriptional regulator of hypoxia, consists of two subunits, HIF-1α and HIF-1β, in which HIF-1α expression is regulated by the cellular oxygen concentration. Hypoxia preconditioning induces endogenous regulatory mechanisms in the body, including the expression of multiple genes and the activation of different transcription factors. HIF-1 is closely related to the formation of cerebral ischemic tolerance. Hypoxia may up-regulate the expression of HIF-1 Expression and activity, thereby inducing the expression of its target gene, inducing the formation of cerebral ischemic tolerance to protect brain tissue.