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本文报道了海蒽酮等对曼氏血吸虫活动力的体外试验结果。曼氏血吸虫的活动系通过光电管的电子变化自动计表,“微小活动观察”(micro-activity cage),应用计算机描绘活动的速率和型式并进行比较。培养液中的5羟色胺(5-HT)为10~(-3)M时,强烈地兴奋虫的神经肌肉系统。低浓度的海蒽酮,10~(-5)～10~(-6)M,刺激虫的活动,浓度大于10~(-4)M时,对虫的活动不引起改变或抑制其活动。在低浓度海蒽酮作用下的虫培养液中加入5-HT时,虫的活动异常加强;但在海蒽酮10~(-4)M的培养液中加入5-HT时,虫的活动就不那么显著加强。在海蒽酮的继续作用下,5-HT
In this paper, we report the results of in vitro experiments on the activity of marine anthrone against Schistosoma mansoni. The activity of Schistosoma mansoni was automatically quantified by electronic changes of the photocell, a “micro-activity cage”, and the rate and type of activity were plotted by computer and compared. When the serotonin (5-HT) in the culture medium is 10 -3 M, the neuromuscular system of the insect is strongly excited. Low concentrations of sea anthrone, 10 ~ (-5) ~ 10 ~ (-6) M, stimulate the activity of insects, concentration greater than 10 ~ (-4) M, the worm activity does not cause change or inhibit its activity. When 5-HT was added into the worm culture medium under the action of low concentration of sea-anthrone, the activity of the insect was enhanced abnormally. However, when 5-HT was added to the culture solution of sea-anthrone 10 -4 M, Not so significantly strengthened. In the continued role of sea anthrone, 5-HT