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二氧化硅(SiO_2)对肺泡巨噬细胞的损伤被认为是矽肺发病的首要环节。因此,能对抗或延缓SiO_2的这种细胞毒作用,保护巨噬细胞的药物就可能具有防治矽肺的作用。目前已观察到,柠檬酸铝(柠铝)对治疗实验性动物矽肺及矽肺病人均有一定的疗效,并经体外实验证明,柠铝对SiO_2诱发的巨噬细胞毒性有明显的拮抗作用。然而,有关SiO_2诱发巨噬细胞毒性的机理和柠铝保护作用的
Damage of alveolar macrophages by silica (SiO 2) is considered as the primary link of silicosis. Therefore, to antagonize or delay the cytotoxic effect of SiO_2, macrophages to protect drugs may have the role of prevention and treatment of silicosis. It has been observed that aluminum citrate (lemon aluminum) for the treatment of experimental animals, silicosis and silicosis patients have a certain effect, and in vitro experiments show that lemon aluminum SiO 2 induced macrophage cytotoxicity obvious antagonism. However, the mechanism of SiO 2 -induced macrophage cytotoxicity and the protective role of aluminum