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目的探讨多西他赛联合顺铂治疗晚期非小细胞肺癌的疗效和毒副反应。方法应用多西他赛75mg/m2联合顺铂75mg/m2方案治疗38例晚期非小细胞肺癌患者。结果总有效率达36.8%,其中初治组有效率为41.2%,复治组有效率为33.3%。主要毒副反应为骨髓抑制、恶心呕吐、腹泻及周围神经炎等。结论多西他赛联合顺铂治疗晚期非小细胞肺癌有较好疗效,毒副反应可耐受。
Objective To investigate the efficacy and side effects of docetaxel plus cisplatin in the treatment of advanced non-small cell lung cancer. Methods 38 patients with advanced non-small cell lung cancer were treated with docetaxel 75mg / m2 and cisplatin 75mg / m2. Results The total effective rate was 36.8%, of which the effective rate of initial treatment group was 41.2%, and the effective rate of retreatment group was 33.3%. The main side effects of bone marrow suppression, nausea, vomiting, diarrhea and peripheral neuritis. Conclusion Docetaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer has a good curative effect, toxic side effects can be tolerated.