中枢神经系统的损伤和神经退行性疾病的移植治疗需要重要的细胞来源。如今,细胞来源的研究主要集中于诱导多功能干细胞(i PSCs)技术和体细胞直接转分化技术。现已有多种方式实现了高效诱导神经元的转化和成熟,而且从安全性角度考虑,转化方式也正逐渐得到完善。根据现在的诱导神经元的研究进展,对其安全性和有效性进行评估。 Transplantation of central nervous system injuries and neurodegenerative diseases requires an important source of cells. Today, the research of cell sources mainly focuses on the induction of pluripotent stem cells (iPSCs) and somatic direct transdifferentiation. Now there are many ways to achieve the efficient transformation of neurons and mature, but also from a security point of view, the transformation is gradually being improved. Based on the current research progress of neuronal induction, its safety and efficacy are evaluated.