To investigate the effects of lanthanum chloride on binding of LPS to monocyte and CD14 expression upregulation induced by LPS, human monocytes were analyzed by flow cytometry (FCM). The results indicated that lanthanum chloride could decrease the binding rate of LPS with monocyte significantly. LPS upregulated the expression of CD14 on monocyte in dose dependant manner, however, lanthanum chloride could inhibit the increase of CD14 expression on monocytes by halves. Cellular & Molecular Immunology.2004; 1(5):392-394.