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晚近有迹象提示瘤型麻风病人的免疫无反应性是特异的、或者至少选择性地针对麻风菌抗原,而对其它普通回忆抗原的细胞免疫(CMI)反应仍然正常.瘤型麻风病人这种不反应性的机制可能是(1)免疫耐受;(2)抗体介导的抑制CMI;(3)遗传素质;(4)主动免疫抑制.本文研究麻风菌在体外诱发对T细胞促有丝分裂原反应的抑制作用,并探索瘤型麻风病人的不反应性可能涉及的抑制细胞性质.试验方法:61个麻风病人(LL35;BL及BT15;TT11)和30个健康人的外周血用聚蔗糖——泛影钠梯度法(Ficoll-Hypaque gradie-
There are recent indications that immunologic anergy in patients with leprous leprosy is specific or at least selectively directed against leprosy antigens while cellular immune response (CMI) responses to other common memory antigens remain normal. The mechanism of reactivity may be: (1) immune tolerance; (2) antibody-mediated inhibition of CMI; (3) genetic predisposition; (4) active immunosuppression.In this paper, leprosy in vitro induced mitogenic response to T cells , And to explore the inhibitory cell properties that may be involved in the non-responsiveness of leprosy patients.Methods: The peripheral blood of 61 leprosy patients (LL35; BL and BT15; TT11) and 30 healthy people were treated with Ficoll- Pancreatic sodium gradient method (Ficoll-Hypaque gradie-