目前,普遍使用乙胺嘧啶预防疟疾。但该药过量有引起中毒,甚至死亡的危险,尤其是儿童,国内外已有不少报道,应引起注意。我院于1972年收治2例乙胺嘧啶中毒儿童,其中1例死亡,1例后遗严重中毒性脑病,现报告如下。例1:夏××,女,2周岁。于1972年9月13日上午6时自服乙胺嘧啶14片(含87.5毫克),4小时后出现剧烈呕吐,呼吸困难,急诊入院。体温41.3℃,深度昏迷,头部大汗淋漓,瞳孔极度散大, Currently, pyrimethamine is commonly used to prevent malaria. However, excessive doses of this medicine cause the risk of poisoning and even death, especially for children. There have been many reports at home and abroad that should attract attention. Two cases of pyrimethamine poisoning were admitted to our hospital in 1972, of which 1 died and one was followed by severe toxic encephalopathy. The report is as follows. Example 1: summer × ×, female, 2 years old. At 6 o’clock on the September 13, 1972 self-serving pyrimethamine 14 tablets (including 87.5 mg), 4 hours after severe vomiting, difficulty breathing, emergency admission. Body temperature 41.3 ℃, depth of coma, sweating head, pupils extremely scattered,