论文部分内容阅读
在灵长类用HCGβ亚基免疫具有抗生育作用,但产生的抗体仍与人垂体的LH发生交叉反应,因而难于在临床推广。为解决抗体特异性问题,在雌性狒狒曾观察过用HCGβ亚基的C端肽作为抗原免疫对生育力的影响。但因所用动物数量过少难以得出结论。作者进一步在狒狒观察了用HCGβ亚基C端肽免疫的抗生育作用。选用30只雌性狒狒,周期长短变化不超过三天,并在实验前的连续三个周期中根据血浆孕酮水平证实正常排卵。将动物任意分为两组,每组15只。对照组用破伤风抗毒素免疫,实验组用β-HCGC端
Immunization with primate HCG beta subunit has anti-fertility effects, but the antibodies produced are still cross-reactive with human pituitary LH and thus difficult to be clinically promoted. To address the issue of antibody specificity, the effects of the immunization of C-telopeptides with the HCG beta subunit as antigen on fertility have been observed in female baboons. However, the number of animals used is too small to draw conclusions. The authors further observed in Baboons the anti-fertility effects of C-terminal peptide immunization with HCG beta subunit. Thirty female baboons were selected and their duration varied by no more than three days. Normal ovulation was confirmed on the basis of plasma progesterone levels in three consecutive pre-experiment cycles. The animals were randomly divided into two groups of 15. Control group immunized with tetanus antitoxin, experimental group with β-HCGC side