疫苗类成品从分包装到运输保存均要求冷链保护,在包装环节脱离冷链也有时限要求[1]。疫苗制品进行包装时通常会使用裹包机,在裹包机上,需使用超过100℃加热板进行封膜并整形,这一相对较短的加热升温过程对于制品的影响易被忽视,但实际上这一影响是存在的,并且在特殊情况下,受热时间会加长(如故障停机或者是暂停待料),从而造成 Vaccine finished products from sub-package to transport preservation require cold-chain protection, in the packaging segment from the cold chain also have time-limit requirements [1]. Vaccine products are usually packaged using a wrapping machine, wrapping machine, the need to use more than 100 ℃ heating plate sealing and shaping, the relatively short heating process for the impact of the product easily overlooked, but in fact this An effect exists, and in exceptional circumstances, the heating time will be extended (such as downtime or suspended pending), resulting in