论文部分内容阅读
目的探讨高白细胞急性淋巴细胞白血病(HLALL)的临床特征及免疫表型特点。方法使用流式细胞术对19例HLALL和76例非高白细胞急性淋巴细胞白血病(NHLALL)进行免疫表型检测,并对结果进行分析。结果与NHLALL相比HLALL的发病年龄较大(t=2.2479,P<0.01),骨髓增生更为活跃(u=4.22,P<0.01),肝、脾浸润更为明显(χ2=18.280、4.222,P<0.05),缓解率低(χ2=7.675,P<0.05),HLALL多系列抗原的共表达与NHLALL比较发生率更高(χ2=4.667,P<0.05),在HLALL中出现最多的髓系抗原是CD13,与HLALL比较差异有统计学意义(χ2=5.296,P<0.05)。结论 HLALL的发生与年龄,骨髓增生程度,多系列抗原,特别是CD13的共表达有关。肝、脾浸润更为明显,预后不良。
Objective To investigate the clinical features and immunophenotypic features of HLALL. Methods Flow cytometry was used to detect the immunophenotype of 19 HLALLs and 76 non-HLBCL patients, and the results were analyzed. Results The age of onset of HLALL was higher than that of NHLALL (t = 2.2479, P <0.01), the myeloproliferation was more active (u = 4.22, P <0.01) and the infiltration of liver and spleen was more obvious (χ2 = 18.280, (Χ2 = 7.675, P <0.05). The coexpression of HLALL multi-series antigens was higher than that of NHLALL (χ2 = 4.667, P <0.05), and the most common myeloid The antigen was CD13, which was statistically different from HLALL (χ2 = 5.296, P <0.05). Conclusions The occurrence of HLALL is related to the age, the degree of myeloproliferation, and the co-expression of multiple series of antigens, especially CD13. Liver, spleen infiltration is more obvious, the prognosis is poor.