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以水为溶剂,设计玻璃保温装置,采用静电纺丝技术制备了葡萄籽多酚/明胶复合纤维,系统探讨了浓度、温度、电压、流速等工艺条件以及葡萄籽多酚含量对葡萄籽多酚/明胶复合纤维形貌的影响。结果表明:当明胶浓度为24wt%时,随着温度和电压的增大,纤维平均直径先减小后增大,随葡萄籽多酚含量增大,纤维平均直径增大。通过加入适量葡萄籽多酚,可将纺丝速度从0.25mL/h提高到0.90mL/h,显著提高了工作效率;当葡萄籽多酚与明胶的质量比≥1∶30时,纤维表面出现串珠;当葡萄籽多酚与明胶的质量比≥1∶20时,可纺性变差。在明胶浓度为24wt%,葡萄籽多酚与明胶质量比为1∶50,控制温度55℃,电压20kV,接收距离12cm,速率0.90mL/h的条件下,制备了纤维直径分布集中,平均直径为515nm的葡萄籽多酚/明胶复合纤维。明胶溶液中加入适量葡萄籽多酚不仅大大提高了纺丝效率,同时由于其良好的抗菌活性和对明胶的交联作用,使复合纤维膜可广泛应用于生物医药领域,特别是创伤敷料方面。
With water as solvent, glass insulation device was designed. The grape seed polyphenol / gelatin composite fiber was prepared by electrospinning technique. The effects of concentration, temperature, voltage and flow rate on the polyphenol / / Gelatin composite fiber morphology. The results showed that when the gelatin concentration was 24wt%, the average diameter of fibers decreased firstly and then increased with the increase of temperature and voltage. With the increase of polyphenol content of grape seeds, the average fiber diameter increased. By adding the appropriate amount of grape seed polyphenols, the spinning speed can be increased from 0.25mL / h to 0.90mL / h, significantly improving the work efficiency; when the mass ratio of grape seed polyphenol to gelatin ≥1:30, the fiber surface appears Beaded; when the mass ratio of grape seed polyphenols and gelatin ≥1:20, spinnability worsened. Under the conditions of gelatin concentration 24wt%, grape seed polyphenol and gelatin weight ratio 1:50, control temperature 55 ℃, voltage 20kV, receiving distance 12cm and rate 0.90mL / h, 515 nm grape seed polyphenol / gelatin conjugate fiber. The addition of the appropriate amount of grape seed polyphenols to the gelatin solution not only greatly improves the spinning efficiency, but also enables the composite fiber membrane to be widely used in the fields of biomedicine, especially the wound dressing due to its good antibacterial activity and the crosslinking effect on gelatin.