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目的 研究甲亢病人的钙磷代谢、骨代谢和骨密度改变及机理。方法 对３８ 例甲亢病人治疗前后用单能 Ｃ Ｔ（ Ｓ Ｅ Ｑ Ｃ Ｔ） 测定骨密度（ Ｂ Ｍ Ｄ） 变化，用双抗体法测定血Ⅰ型胶原羧基端前肽（ Ｃ Ｉ Ｃ Ｐ） ，骨钙素（ Ｂ Ｇ Ｐ） 和尿脱氧吡啶酚（ Ｄ Ｐ Ｄ） 排泄率的变化。结果 治疗前 Ｂ Ｍ Ｄ 明显降低［ 男（１２０±８） ｍｇ／ｃｍ ３ Ｈ Ａ，女（１１４ ±７ ．２） ｍ ｇ／ｃｍ ３ Ｈ Ａ］ 治疗后都恢复正常。血 Ｂ Ｇ Ｐ 男性从（１５ ．２ ±７ ．９）μｇ／ Ｌ 下降到（７ ．５ ±２ ．８）μｇ／ Ｌ（ Ｐ＜ ０ ．０５） ，女性从（１６ ．４ ±７ ．１）μｇ／ Ｌ 下降到（６ ．８ ±２ ．１） μｇ／ Ｌ（ Ｐ＜ ０ ．０１） 。血 Ｃ Ｉ Ｃ Ｐ 男性从（１８５ ±２３ ．５）ｎｇ／ ｍｌ 下降到（７０ ±１０ ．４）ｎｇ／ ｍｌ（ Ｐ＜ ０ ．０５） ，女性从（１６４ ±１６ ．２）ｎｇ／ ｍｌ 下降到（６９ ±９ ．２）ｎｇ／ ｍｌ（ Ｐ＜ ０ ．０５） 。尿 Ｄ． Ｐ． Ｄ 男性从（１３ ．７ ±２ ．５）ｎ Ｍ／ ｍ Ｍ 下降到（３ ．４ ±１ ．０） ｎ Ｍ／ ｍ Ｍ（ Ｐ＜ ０ ．０１） ，女性从（１４ ．６ ±２ ．３）ｎ Ｍ／ ｍ Ｍ 下降到（４ ．５ ±１ ．２
Objective To study the changes of calcium and phosphorus metabolism, bone metabolism and bone mineral density in hyperthyroidism patients and its mechanism. Methods The bone mineral density (B M D) was measured in 38 patients with hyperthyroidism before and after treatment. The C Ⅰ C P of blood type Ⅰ collagen was measured by double antibody method. Osteocalcin (B G P) and urinary deoxypyridinol (D P D) excretion rate changes. Results The B M D significantly decreased before treatment (120 ± 8 mg / cm 3 H A for men and 114 ± 7 2 m g / cm 3 H A for women). Blood B G P decreased from (15.2 ± 7.9) μg / L to (7.5 ± 2.8) μg / L (P <0.05) in women with B (P <0.05) ) Μg / L to (6 .8 ± 2 .1) μg / L (P <0.01). The level of serum C I C P decreased from (185 ± 23.5) ng / ml to (70 ± 10.4) ng / ml (P <0.05) in women and decreased from (164 ± 16.2) ng / ml in women To (69 ± 9 .2) ng / ml (P <0.05). Urine D. P. D males decreased from (13.7 ± 2.5) n M / m M to (3.4 ± 1.0) n M / m M (P <0.01), and females from (14.6 ± 2. 3) n M / m M decreased to (4.5 ± 1.2