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作者曾报道,绵羊妊娠早、中期切除胎羊甲状腺,复制出类似于克汀病的动物模型。本文在胚胎第131~143天切甲,出生时的发育情况与对照组已无显著差异。因此这时已不是甲状腺激素对脑发育的临界期。
The authors have reported that sheep early and mid-gestation removal of fetal sheep, replicate animal models similar to cretinism. This article in the first 131 to 143 days of embryo cutaneous, the development of birth and the control group no significant difference. So this time is not the critical period of thyroid hormone on brain development.