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目的 :探讨低分子量肝素在肾综合征出血热血液透析中抗凝效果及安全性。方法 :对 6 2例肾综合征出血热行血液透析的患者随机分为两组 ,分别用低分子量肝素及普通肝素抗凝。结果 :低分子量肝素组比普通肝素组体外循环凝血发生率低 ,出血危险性小 ,对APTT的影响小 (P <0 .0 1)。结论 :低分子量肝素在肾综合征出血热血液透析中疗效理想 ,应用方便 ,副作用少。
Objective: To investigate the anticoagulant effect and safety of low molecular weight heparin in hemodialysis with hemorrhagic fever with renal syndrome. Methods: Sixty two patients with hemorrhagic fever with renal syndrome hemodialysis were randomly divided into two groups, with low molecular weight heparin and unfractionated heparin respectively. Results: The low-molecular-weight heparin group had a lower incidence of coagulation after cardiopulmonary bypass and a lower risk of bleeding compared with unfractionated heparin group, which had a small effect on APTT (P <0.01). Conclusion: Low molecular weight heparin is effective in hemodialysis with hemorrhagic fever with renal syndrome, with convenient application and few side effects.