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目的:观察金菊鲜地黄汤防治鼻咽癌放疗所致口腔黏膜反应的临床疗效。方法:将200例需行首次常规放疗的鼻咽癌患者采用随机数字表法随机分为两组,两组均采用三维放疗。对照组100例采用常规西医口腔处理,给予生理盐水清洗口腔、鼻咽及口咽部,清洗后采用甲硝唑注射液漱口,每日4~6次;治疗组100例在对照组治疗基础上加服金菊鲜地黄汤(金银花、菊花、鲜地黄、沙参、麦冬、玉竹、太子参、甘草、丹参、川贝母),每日1剂,水煎药汁至200 m L,分早、晚口服。两组均从放疗第1天开始治疗,直至放疗结束判定疗效。结果:治疗组出现放射性口腔黏膜反应的时间、累积放射剂量均较对照组差别有统计学意义(P<0.05);治疗组总放疗时间少于对照组(P<0.05);治疗组治疗后卡氏评分明显高于对照组(P<0.05)。结论:金菊鲜地黄汤能有效防治鼻咽癌放疗所致口腔黏膜反应。
Objective: To observe the clinical effect of “Jinju Xin Di Huang Decoction” in preventing and treating the oral mucosa reaction caused by radiotherapy of nasopharyngeal carcinoma. Methods: A total of 200 patients with nasopharyngeal carcinoma undergoing conventional radiotherapy were randomly divided into two groups using three-dimensional radiotherapy. The control group of 100 cases using conventional Western oral treatment, given saline to clean the mouth, nasopharynx and oropharyngeal, after cleaning with metronidazole injection mouthwash, 4 to 6 times a day; 100 cases of treatment group in the control group based on treatment On top of the decoction, add fresh Radix Rehmanniae Decoction (honeysuckle, chrysanthemum, fresh rehmannia, Radix Aconiti Kusnezoffii, Radix Polygonatum, heterophylla, licorice, Salvia miltiorrhiza, Fritillaria) , Points early, evening oral. Both groups started treatment from the first day of radiotherapy until the end of radiotherapy to determine the efficacy. Results: The time of radiation oral mucosal reaction and the cumulative radiation dose in the treatment group were significantly different from those in the control group (P <0.05). The total radiotherapy time in the treatment group was less than that in the control group (P <0.05) S score was significantly higher than the control group (P <0.05). Conclusion: Jinju Xian Di Huang Tang can effectively prevent and treat nasopharyngeal carcinoma caused by oral mucosal reaction.