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目的：探讨牛磺酸对大鼠创伤脊髓的保护作用。方法：７２只雄性Ｗｉｓｔａｒ大鼠以改良Ａｌｅｎ法（５０ｇｃｍ）打击脊髓致脊髓损伤。结果：牛磺酸可明显减轻脑脊液蛋白漏出（０６６±０１７ｖｓ１２１±０４５ｇ／Ｌ，Ｐ＜００５）和组织水肿（湿重／干重比值３３９±０１２ｖｓ３５３±０１６，Ｐ＜００１）；减少组织ＭＤＡ生成（２４８２２±１２９５ｖｓ２９９４５±４３５２ｎｍｏｌ／ｇｄｗ，Ｐ＜００５）；减轻组织Ｃａ２＋负荷（１３８３５±３２９３ｖｓ１９６６２±４８６１ｐｍｏｌ／ｇｄｗ，Ｐ＜００１）；降低血浆内皮素含量（１６４３±２９７ｖｓ２０３８±３４０ｎｇ／Ｌ，Ｐ＜００５）。结论：牛磺酸可能通过清除氧自由基、稳定细胞膜，防止钙超载和调整血管内源性血管活性物质发挥其保护作用。
Objective: To investigate the protective effect of taurine on traumatic spinal cord in rats. Methods: Seventy - two male Wistar rats were treated with modified Alen method (50gcm) against spinal cord injury. Results: Taurine significantly reduced CSF leakage (066 ± 017vs121 ± 045g / L, P <005) and tissue edema (wet weight / dry weight ratio 339 ± 0 12vs353 ± 016, P <001), and decreased the MDA production (24822 ± 1295 vs29945 ± 4352 nmol / gdw, P <005) 35 ± 3293vs19662 ± 4861pmol / gdw, P <001), and decreased the plasma endothelin level (1643 ± 297 vs2038 ± 3.40ng / L, P <005). Conclusion: Taurine may exert its protective effect by scavenging oxygen free radicals, stabilizing cell membrane, preventing calcium overload and regulating endogenous vasoactive substances in blood vessels.