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丙谷胺即二丙谷酰胺(Proglumide),化学名DL-4-苯甲酰胺-N,N-二正丙基戊酰胺酸,是一种胃泌素受体拮抗剂,用以治疗消化性溃疡。 口服丙谷胺后在胃肠道吸收迅速、完全。如与碱性药物同服,并不影响其吸收。口服2小时血中浓度达高峰,应用治疗量时其最小有效血浓度为2μg/ml。吸收后主要分布于肝、肾和胃肠道,血浆半衰期约为33小时。最后由肠道及肾脏排出。反复应用未见蓄积性毒性作用。
Proglumide Proglumide (Proglumide), the chemical name of DL-4-benzamide-N, N-di-n-propyl glutamyl acid, is a gastrin receptor antagonist for the treatment of digestive ulcer. After oral administration of proglumide rapidly absorbed in the gastrointestinal tract, completely. As with the same basic drugs, does not affect its absorption. Oral 2 hours blood concentration reached its peak, the application of treatment of the minimum effective blood concentration of 2μg / ml. Absorbed mainly in the liver, kidney and gastrointestinal tract, the plasma half-life of about 33 hours. Finally, by the gut and kidneys. Repeated application no cumulative toxic effects.