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目的探讨外周血中部分炎性因子与短暂性脑缺血发作(TIA)的相关性。方法对43例TIA患者和39例健康体检者(对照组)外周血中C-反应蛋白(CRP)、D-二聚体(D-D)、血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制因子-1(TIMP-1)水平进行检测,并进行多因素Logistic回归分析。结果与TIA相关的单因素分析显示TIA患者血CRP、D-D、MMP-9和TIMP-1水平高于对照组,两组比较差异有统计学意义;多因素Logistic回归分析提示:TIMP-1与是否患病关系最密切。结论血中部分炎性因子在TIA后都有不同程度升高,它们参与了TIA的病理生理过程,与TIA密切相关。
Objective To investigate the correlation between some inflammatory factors in peripheral blood and transient ischemic attack (TIA). Methods The serum levels of C-reactive protein (CRP), D-dimer (DD), serum matrix metalloproteinase-9 (MMP-9) Proteasome inhibitor 1 (TIMP-1) levels were detected and multivariate logistic regression analysis. Results TIA-related univariate analysis showed that blood levels of CRP, DD, MMP-9 and TIMP-1 in TIA patients were higher than those in control group, and there was significant difference between the two groups. Multivariate logistic regression analysis showed that TIMP-1 and The most closely related illness. Conclusion Some inflammatory factors in blood have different degrees of increase after TIA. They are involved in the pathophysiological process of TIA and are closely related to TIA.