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目的观察丹参多酚酸盐治疗老年不稳定型心绞痛的临床疗效。方法选择不稳定型心绞痛高龄患者共86例,随机分为两组各43例,对照组采用常规药物治疗,治疗组在常规药物治疗的基础上,给予丹参多酚酸盐200 mg,每日1次,共14 d。观察两组患者临床症状改善情况、硝酸酯类用量变化、心电图ST-T改变及治疗前后血小板聚集率、高敏C-反应蛋白、D-二聚体变化。结果治疗组心绞痛症状改善38例(88%),心电图改善28例(65%);对照组分别为30例(70%),16例(37%)。两组比较差异有统计学意义。结论丹参多酚酸盐能更有效改善老年心绞痛症状及心电图ST-T变化,减少心脏不良事件的发生。
Objective To observe the clinical efficacy of salvianolate in the treatment of unstable angina in the elderly. Methods A total of 86 elderly patients with unstable angina pectoris were selected and randomly divided into two groups of 43 cases each. The control group was treated with conventional drugs. The treatment group was given salvianolate 200 mg daily for 1 Times, a total of 14 d. Changes of clinical symptoms, changes of nitrate dosage, change of electrocardiogram ST-T, platelet aggregation rate, high-sensitivity C-reactive protein and D-dimer before and after treatment were observed. Results The improvement of angina in treatment group was improved in 38 cases (88%) and electrocardiogram in 28 cases (65%). The control group was 30 cases (70%) and 16 cases (37%). The difference between the two groups was statistically significant. Conclusion Salvianolic acid polyphenols can effectively improve the symptoms of angina and electrocardiogram ST-T changes and reduce the incidence of adverse cardiac events.