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1研究背景目前全球有数百万老年人正在受到一种渐进性神经退行性脑病——阿尔茨海默病(Alzheimer’s disease,AD)的折磨。遗憾的是,由于缺乏有效的治疗选择,预计到2050年这一数字将超过7千万。AD是一种复杂的综合征,其病因包括多种因素,如β-淀粉样蛋白聚集、tau蛋白聚集和乙酰胆碱水平降低等。胆碱能神经传递障碍和AD之间的关联为将乙酰胆碱酯酶(activity of acetylcholine esterase,
1 Research Background Millions of elderly people worldwide are now afflicted with a progressive neurodegenerative brain disease, Alzheimer’s disease (AD). Unfortunately, the number is projected to exceed 70 million by 2050 due to the lack of effective treatment options. AD is a complex syndrome whose causes include a variety of factors such as beta-amyloid aggregation, tau protein aggregation and decreased levels of acetylcholine. The link between cholinergic neurotransmission disorder and AD is the activity of acetylcholine esterase