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Aims: To determine the haematological effects of iron supplementation in predo minantly breast fed term low birth weight (LBW) infants. Methods: Seventy three healthy term LBW ( < 2500 g), predominantly breast fed infants aged 50-80 days were randomised into two groups to receive either iron (3 mg/kg/day) (iron suppl emented (IS) group; n = 37) or placebo drops (placebo (P) group; n = 36). Haemat ological parameters and anthropometrywere measured at baseline and repeated afte r four and eight weeks. Results: A total of 62 subjects (32 in the IS group and 30 in the P group) came for the first follow up and 26 (13 in the IS group and 1 3 in the P group) reported for the second visit. There were no significant diffe rences in serum ferritin and anthropometry. However, covariates (infant age, hae moglobin, and ferritin, and maternal haemoglobin) adjusted haemoglobin change wa s significantly higher in the IS group after fourweeks (4.6 g/l;95%CI 0.5 to 8.8) and eightweeks (8.6 g/l; 95%CI 1.8 to 15.4). Conclusions: Iron supplem entation in a therapeutic dose in term breast fed LBW infants results in a margi nal increase in haemoglobin. The functional benefit of this haemoglobin rise req uires further evaluation.
Aims: To determine the haematological effects of iron supplementation in predo minantly breast fed term low birth weight (LBW) infants. Methods: Seventy three healthy term LBW (<2500 g), predominantly breast fed infants aged 50-80 days were randomized into two n = 37) or placebo drops (placebo (P) group; n = 36). Haemat ological parameters and anthropometrywere measured at baseline and Results: A total of 62 subjects (32 in the IS group and 30 in the P group) came for the first follow up and 26 (13 in the IS group and 13 in the P group) However, covariates (infant age, haemoglobin, and ferritin, and maternal hemoglobin) adjusted haemoglobin change wa s significantly higher in the IS group after fourweeks (4.6 95% CI 0.5 to 8.8) and eightweeks (8.6 g / l; 95% CI 1. 8 to 15.4). Conclusions: Iron supplementation in a therapeutic dose in term breast fed LBW infants results in a margi nal increase in hemoglobin. The functional benefit of this haemoglobin rise req uires further evaluation.