SMXL6/7/8: Dual-Function Transcriptional Repressors of Strigolactone Signaling

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Strigolactones (SLs) were recently identified as a new class of carotenoid-derived plant hormones that regulates many aspects of plant development and responses to both biotic and abiotic stresses.Active SLs are synthesized from its substrate β-carotene with four success ve y act ng enzymes, including DWARF27 (D27), DWARF17 (D17), DWARF10 (D10), and MORE AXlLLARY GROWTH 1 (MAX1), and perceived by a noncanonical α/β-hydrolase receptor DWARF14 (D14).In the present of SLs, D14 is activated by ligand hydrolysis and conformational change.Activated D14 then recruits the F-box protein MORE AXILLARY GROWTH2(MAX2)/D3 and ASK1 protein to form an SCF complex, which interacts with the signaling repressor proteins SMXLs/D53, and triggers 26S proteasome-mediated degradation of SMXLs/D53 proteins, thus unleashing expression of SL-responsive downstream genes from the inhibition of SMXLs/D53, and subsequently SL responsiveness.Apparently, this hormone signalingactivated proteolysis of central repressor proteins bears a high degree of similarity to the signaling mechanisms of a number of other plant hormones, including auxin, jasmonate, and gibberellin (Waters et al., 2017).
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