论文部分内容阅读
报告了甲基丙烯酸β－羟乙酯（ＨＥＭＡ）在室温下进行辐射聚合制备双氢埃托啡（ＤＨＰ）缓释制剂的研究，结果表明：药物接受１６．７５ｋＧｙ照射后其红外紫外光谱未见明显改变，说明ＤＨＰ受１８．７５ｋＧｙ以下的辐射对其结构没有影响。ＨＥＭＡ所固化的ＤＨＰ体外释放稳定而持久，小鼠皮下包埋实验显示出数日的止痛效果，小鼠皮肤病理表明仅有轻微的异物反应．
The study on the preparation of dihydroerotetrahydro (DHP) sustained-release preparation by radiation polymerization of β-hydroxyethyl methacrylate (HEMA) at room temperature was reported. The results showed that the infrared absorption spectrum of the drug did not reach 16.75 kGy Significantly changed, indicating DHP by 18.75kGy the following radiation has no effect on its structure. In vitro release of HEMA-stabilized DHP was stable and sustained. Subcutaneous burial experiments in mice showed a few days of analgesic effect and mouse skin pathology showed only slight foreign body reaction.