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目的：探讨急性高原脑水肿的发生机理；方法：实验观察了不同海拔梯度下小鼠及含水量的改变及其与脑水肿的关系；结果：小鼠由低海拔区快速进入高海拔区后脑组织的湿干比值和含水量均有增高（P＜0．01），以进入高海拔区后的第7天为最高峰；结果：组织学观察表明，此时脑神经细胞肿胀，胞浆内有空泡变性，胶质细胞和微血管周围有明显空晕；结论：由低海拔区快速进入高海拔区后可致脑水肿形成。
Objective: To investigate the mechanism of acute high altitude brain edema. Methods: The changes of mice and water content at different altitudes and their relationship with cerebral edema were observed. Results: The mice rapidly entered the high altitude area from the low altitude to the brain (P <0.01), and reached its peak on the 7th day after entering the high altitude area.Results: Histological observation showed that at this time, the brain cells were swollen and cytoplasm had Vacuolar degeneration, glial cells and microvessels around the obvious empty halo; Conclusion: from low altitude area quickly into high altitude area can cause brain edema formation.