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米索前列醇(简称米索)是一种合成的前列腺E_1类似物,因具有前列腺素E_1的作用,故可使宫颈纤维组织软化,宫颈变软,宫口松弛达到促进产程进展的目的.而对于不同年龄、不同产次的宫颈作用差异不明显.以前常用口服给药,可产生恶心、腹痛等副作用,为避免以上不良反应,我院在引产中改为外用药,临床取得满意效果,现总结如下:1 资料与方法1.1 一般资料:研究对象为足月妊娠,单胎头位,无头盆不称和影响产程进展的合并症及并发症.随机分为二组,米索组180例,对照组160例,年龄22岁～35岁,平均27.6岁.孕周39～42周,平均40周.未临产或持续性不规律宫编者,胎膜早破,宫颈开大均小于1cm以下者.病例选择二组无明显差异.1.2 方法:米索组患者取截石位,常规消毒外阴、阴道,戴无菌手套,置米索50mg于阴道后穹隆处,平卧1～2小时后可随意活动,对照组给 0.5 %催产素引产,开始 8～10滴/分,间隔20～30分钟调整一次滴数,每次递增5滴/分,直到规律宫缩开始,对于宫颈管未展平,质地较韧者给予安定10mg静脉缓推,以软化宫颈促进产程进展.
Misoprostol (referred to as misoprostol) is a synthetic prostate E_1 analogue, because of the prostaglandin E_1 role, it can make the cervical fibrosis, cervical softening, cervix relaxation to achieve the purpose of promoting labor progress. For different ages, different parity of cervical production was not obvious.Oral commonly used before oral administration can produce nausea, abdominal pain and other side effects, in order to avoid the above adverse reactions, the hospital in the induction of labor to change the external medicine, clinically satisfactory results, and now Summarized as follows: 1 Materials and Methods 1.1 General Information: The study object for full-term pregnancy, single head position, headless basin and affect the progress of complications and complications were randomly divided into two groups, 180 cases of misoprostol , The control group of 160 cases, aged 22 to 35 years old, an average of 27.6 years old, gestational age 39 to 42 weeks, an average of 40 weeks.No labor or persistent irregular uterus, premature rupture of membranes, cervix open less than 1cm .1.2 Methods: patients with misoprostol lithotomy position, routine disinfection of the vulva, vagina, wearing sterile gloves, homeopathic 50mg misoprostol at the vaginal fornix, after lying 1 to 2 hours Can be free to move, the control group to 0.5% oxytocin abortion, beginning 8 to 10 Drops / min, interval 20 to 30 minutes to adjust the number of drops, each increment of 5 drops / min, until the beginning of regular contractions for the cervix is not flat, the texture is more robust given intravenous diastolic 10mg to soften the cervix to promote Production progress.