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目的了解我院2010年所收集的严重的和新的药品不良反应(ADR)的药物分布及其所致症状。方法对我院2010年收集的89例严重的或新的ADR报告,按ADR级别、临床表现、涉及的药品、转归、报告质量等进行统计分析。结果 89例ADR中以过敏性反应为临床表现的有58例,占65.17%;45.45%的严重ADR由抗菌药物引起,38.10%的新的ADR由中成药引起,甲巯咪唑引起11例严重ADR。结论应重视并加强ADR监测工作,尤其是对中成药所致ADR的监测,以尽量减少或避免ADR的发生,同时应做到病例报告真实可靠、分级准确。
Objective To understand the drug distribution and the symptoms caused by severe and new drug adverse reactions (ADRs) collected in our hospital in 2010. Methods 89 cases of serious or new ADR collected in our hospital in 2010 were analyzed statistically according to ADR grade, clinical manifestations, drugs involved, outcome and quality of reports. Results Of the 89 ADRs, 58 (65.17%) were allergic reactions, 45.45% were caused by antimicrobial agents, 38.10% of new ADRs were caused by proprietary Chinese medicines, and methimazole caused 11 severe ADRs . Conclusion The monitoring of ADR should be emphasized and strengthened, especially the monitoring of ADR caused by proprietary Chinese medicines, so as to minimize or avoid the occurrence of ADR. At the same time, the report of cases should be reliable and accurate.