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根据Videback报道急性心肌梗塞发病24小时内,患者血浆中儿茶酚胺含量增加,其含量与心律不齐的发生成正比关系。Sutherland等发现血液中儿茶酚胺与细胞膜上的β—受体结合时,细胞膜上的腺甙酸环化酶即被活化,并催化ATP变为环一磷酸腺甙(cAMP),故血浆cAMP含量可以反映血中儿茶酚胺的水平。而后者既与心律紊乱有关,推测血中cAMP含量也有类似变化。
According to Videback reported within 24 hours of the onset of acute myocardial infarction, plasma catecholamines in patients with an increase in its content is proportional to the incidence of arrhythmia. When Sutherland et al. Found that blood catecholamines bind to the β-receptor on the cell membrane, the adenylate cyclase on the cell membrane is activated and catalyzes the change of ATP to cAMP, so the plasma cAMP level can reflect Blood levels of catecholamines. The latter is not only related to cardiac rhythm disorders, suggesting that there is a similar change in the level of cAMP in blood.