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宫颈癌是妇科肿瘤中的第二大常见肿瘤,现已明确人乳头瘤病毒(HPV)感染是宫颈癌的主要致病因素,但并非所有HPV感染都会导致宫颈癌。HPV L1蛋白是HPV的主要衣壳蛋白,其表达与HPV的复制及其早期感染密切相关。近年研究表明,在目前细胞学基础上检测病变组织HPV L1蛋白可提高宫颈病变筛查及预测病变进展的准确度,预防宫颈病变的过度诊治。综述HPV L1在预测宫颈病变的发展及预后的科学性及实用性,以寻找更加合理的筛查流程,对不同患者选择不同的治疗方案。
Cervical cancer is the second most common tumor in gynecologic tumors. It has been clarified that human papillomavirus (HPV) infection is the main causative agent of cervical cancer. However, not all HPV infections cause cervical cancer. HPV L1 protein is the major capsid protein of HPV, and its expression is closely related to the replication of HPV and its early infection. In recent years, studies have shown that the detection of HPV L1 protein in the lesion based on the current cytology can improve the screening of cervical lesions and predict the progress of the lesion, and prevent the excessive diagnosis and treatment of cervical lesions. Review HPV L1 in predicting the development and prognosis of cervical lesions scientific and practical in order to find a more reasonable screening process for different patients choose a different treatment options.